I can't believe the recent negative feedback which to me is a travesty and must be either uninformed or biased. I'm a health professional and juggle hundreds to thousands of priorities. I have tried countless to do methods over the years from paper to computers, trying to get a better handle on the priorities of modern life which which seem to become more and more complicated despite advances in technology . Omnifocus is by far away the most useful application for better controlling this that I have every tried and a 1+ years later, despite temporarily trying every new do list manager, I still live by it, particularly now with benefit of iphone synchronisation. My wish list is that some form of prioritisation beyond flagging could be implemented to help when juggling hundreds of important items. It is as simple or complicated as you need it to be and extraordinary useful for both to do list and projects.