Moneydance has worked well for me, and has made it possible for me to dump Quicken (hooray!). It's reporting capabilities are limited (especially when it comes to investments), but it does more than enough to support tracking purchases and sales, producing tax-related information, and so on. And it's been way more reliable than any version of Quicken I've used in the last decade.

To get a 5-star recommendation from me, they'd need to beef up the documentation and improve their support for analyzing investments. As it stands today, it's a solid 4-star app.