The latest version does work with Snow Leopard and Ed Hamrick has been very helpful in determining why earlier versions had some problems. A tip - try deleting the vuescan.ini file which you can find at .../Users/yourname/Library/Preferences/vuescan.ini and ensure you are not running it in Rosetta. I think this product is truly excellent and Ed Hamrick is really helpful and keen to ensure his customers are happy.