I’m running 10.4.11. This version seems to take much longer to open for me. When I click on “scan” many times I get the message that the scanner is “busy.” Since I have to force quit to start over, it can take several attempts to actually get Vue Scan to quit. Once I can get it to run it works beautifully as expected. My scanner is an Epson 2450 connected by USB2 and has never been a problem with previous versions.