While I enjoy this type of game, a lot of the recent ones really annoy me in regards to the screen resolutions behavior. This is one of those. Your only choice is between Full Screen and Window mode. In Full Screen, it blows everything up so much as to be somewhat fuzzy on my 30" Apple Cinema HD Display. It also rearranges all of my open windows and desktop icons and I have to put everything back when I quit the game. To me this is very bad "programming etiquette" for a game.

In Window mode, the window is too small to easily see the details of the scenes without eyestrain. And there are no alternate resolutions (window sizes) available.