If you want an enterprise-quality, reliable backup system, I'm still not seeing BRU as a solution. I just had a colleague try BRU and hit some of the the same issues that we hit back in 2004.

There are excellent enterprise backup solutions in the OS X market now, notably NetVault from Bakbone and Time Navigator from Atempo. Be sure to check them out.

By all means, test BRU as a low-priced alternative if you like, but be sure that you put it through its paces: don't just test backups, but also test restores, and do a series of tests over a few days, not just a one-shot test. You're dealing with the safety of your data, and backup operations tend to to just roll along once they're configured and started, so the inability to restore is absolutely huge.

If you select BRU and begin to use it successfully, be sure to implement a regular (monthly or more often) testing regimen to ensure that your backed up data can be properly restored.