After quite a bit of troubleshooting, and checking out the Growl forums, I have confirmed (on my system) that LCC breaks the Growl notifications for most apps on Leopard. After uninstalling, everything works great, but I loose my button functionality. Also, I had an issue the the LCC Update app staying open all the time. LCC has always been sub-par software but it has done the job and never interferred before. This is pretty sad, especially since they have great hardware IMO. I hope they can fix all this in the future. In the meantime I have to find a mouse driver alternative.