I am using my old Mac Mini PPC as a multimedia station and this software + a remote is really a great complement to my little TV setup.
Remote buddy provides a replacement to a mouse, controls Transmission and VLC and many other programs (awaken, itunes, etc.). The menus are slick and they offer direct access to your files (and yet, it offers the choice of the software you will use to open them).
Behaviours can be freely configured and that's probably better since the default one for VLC is not really adapted to the Keyspan Express Remote (meaning that the play/pause/forward buttons are not used by default, etc.).