I've used Endnote for around 10 years. It's become more and more bloated over the years, with each "new" (full-priced) release containing little new save "features" that are completely useless to me and the vast majority of users. Its search function is clumsy, poorly designed, and unreliable, especially for on-line databases (PubMed). It formats bibliiographies almost, but not quite, right, usually forcing me to go back and, say, add periods to the ends of journal names manually.

Bookends is faster, much more intuitive, and generally easier to use. I believe it contains some features that Endnote doesn't have at all -- certainly, if Endnote has them, they are so much harder to use that they may as well not exist. Pubmed searches are effortless, fast, and reliable. Using Word, citations and bibliography formatting have been perfect so far. Bookends imported my Endnote library with no problems at all. WHen I had a question, I got a complete and helpful answer by email within a couple of hours. The new free revisions coming from Bookends are generally bigger steps than Endnotes' annual full-price upgrades.

Highly recommended.