Having read the author's documentation, I found setup for SpamStrainer to be quite easy and straightforward. I am currently testing it with GnuMail. As long you take the time and effort to train SpamStrainer, you will find it is an an effective deterrent to spammers.

A really nice anti-spam application and it's FREEWARE! Kudos to the author(s) for a well designed, thoughtful and complete application! Works with almost any e-mail client; I test almost all of them!