If Gmail (Google Mail) takes off, perhaps Zoe should get a second look. It does basically the same thing on your desk where you can have all the disk space you want, and no one will be snooping through your email trying to figure out what you might buy if the right advertisement was flashed.
i played with Zoe back around v.0.2, but didn't get hooked. I think i'd rather have the best of both worlds: able to file email in folders as well as being able to search it. An excellent search engine would make it less pressing to file everything however, which would be a relief, though.
ZOE
browser based email client
Version: 0.6.3