Well, I've been using Poisoned for a while now, and while I agree this program looks the best, integrates with my Mac the best, searches the best and fastest, doesn't take a week to startup, and many other great features; it has an annoying habit of killing my mp3 downloads. I downloaded 23 versions of one particular song, all different bit rates, sizes and from different servers and each and every one of them was garbled after 12 seconds.
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Oddly this doesn't seem to affect every mp3, and rarely any files except mp3s.
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Apart from being stumped by this problem, Poisoned is always my first port of call for downloading. Only after (and if) it fails me, do I go to one of the inferior rivals.