I'm running 10.3.1 and just followed the directions (rigorously) for installation of the update.

The new program opens, but then it asks for ChemDraw Items. It seems to find the folder by default, but won't accept it when I click "open". It is thus unusable.

I continue to be underwhelmed by this software. At least the old version works. It's PDF compatability seems a bit primitive.

Also, it isn't the only game in town anymore.

Here's a free alternative. It has fewer features, but it is free and works.

http://fink.sourceforge.net/pdb/package.php/xdrawchem