I've tried a lot of P2P apps (Limewire, Aquisition, etc.) and mlMac is the best. Not only it's the best app to connect to edonkey, but it also connects to kazaa and bitTorrent... More networks would be great, but right now, it meets my needs.
Sure, gnutella is great (aquisition is a very good gnutella client) but I cant get that many files from it (specially non-american or rare music files). With mlMac I can, and that's why I like this app.
Besides, it's clean, does the job well, really resumes downloads and it seems quite stable although i've had some quits and crashes (well it's not finished...)
This is app that still needs to evolve a lot (sharing, more networks, stability, etc.), but it might be the next best thing for P2P for Mac since Napster went down...